sl-327

Item no.	V0456-1g
Manufacturer	InvivoChem LLC
CASRN	305350-87-2
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0456CAS #:305350-87-2Purity >=98% Description: SL327 (SL-327) is a novel, potent and selective inhibitor for MEK1/2 with the ability to cross blood brain barrier and block fear conditioning. It inhibits MEK1/2 with IC50s of 0.18 uM/ 0.22uM, and shows little/no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Description: block fear conditioning. It inhibits MEK1/2 References: J Biol Chem. 2000 Nov 24; 275(47):37086-92; J Neurosci. 2000 Dec 1; 20(23):8701-9. References:
Molecular Weight (MW)	335.35
Formula	C16H12F3N3S
CAS No.	305350-87-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 7 mg/mL (20.9 mM)
Solubility (In vivo)	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL
Synonyms	SL 327; SL-327; SL327 Chemical Name: (E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile InChi Key: JLOXTZFYJNCPIS-SQFISAMPSA-N InChi Code: InChI=1S/C16H12F3N3S/c17-16(18, 19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H, 21-22H2/b15-13- SMILES Code: N#C/C(C1=CC=CC=C1C(F)(F)F)=C(N)/SC2=CC=C(N)C=C2

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Amount: 1g

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Delivery expected until 9/6/2024