agk2

Description: AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity. As a cell-permeable epigenetic modifier, AGK2 inhibits SIRT2 with an IC50 value of 3.5 uM and showed little effects on SIRT1 and 3 at concentrations of over 40 uM. AGK 2 increased the level of acetylated tubulin heterodimers in bovine brain. In primary rat astrocytes, AGK-2 (35 uM) significantly inhibited astrocyte viability and proliferation and also inhibited astrocyte activation induced by beta amyloid 1-42 (Abeta 1-42).

References: Science. 2007 Jul 27; 317(5837):516-9; Biochem Biophys Res Commun. 2012 Jan 6; 417(1):468-72; Oncotarget. 2013 Dec; 4(12):2354-65.

Synonym: AGK-2; AGK-2; AGK-2.

Chemical Name: 2-Cyano-3-[5-(2, 5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N

InChi Code: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H, (H, 28, 29)/b14-11+

SMILES Code: O=C(NC1=C2C=CC=NC2=CC=C1)/C(C#N)=C/C3=CC=C(C4=CC(Cl)=CC=C4Cl)O3