nicotinamide-vitamin-b3

Description: Nicotinamide (Vitamin B3; Niacinamide; Nicotinic acid amide), a water-soluble and active form of vitamin B3, is a potent and active component of coenzymes NAD and NADP. It is commonly used as a dietary supplement and medication. As a supplement, it is used by oral administration to prevent and treat pellagra. Nicotinamide also act as an inhibitor of sirtuins. Nicotinamide is also an inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is found as a DNA repair enzyme. The excessive activation of PARP-1, such as ischemia and trauma, can deplete cellular nicotinamide adenine dinucleotide as a substrate and leads to brain cell death eventually.

References: J Biol Chem. 2002 Nov 22; 277(47):45099-107.