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ex-527-selisistat

ex-527-selisistat

Item no.	V0429-50mg
Manufacturer	InvivoChem LLC
CASRN	49843-98-3
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0429CAS #:49843-98-3Purity >=98% Description: Selisistat (formerly SEN-0014196; EX-527) is a novel, highly potent and selective inhibitor of SIRT1 (Sirtuin1, a NAD-dependent and class III histone deacetylase enzyme) with important biological activity. It inhibits SIRT1 with an IC50 of 38 nM in a cell-free assay, and exhibits > 200-fold higher selectivity for SIRT1 over SIRT2, SIRT3 and other deacetylases as well as NAD-processing enzymes. Description: References: Mol Cell Biol. 2006 Jan; 26(1):28-38; Diabetes. 2011 Apr; 60(4):1177-85. References: Related CAS: 848193-69-1 (R-isomer of EX-527); 848193-68-0 (S-isomer of EX-527)
Molecular Weight (MW)	248.71
Formula	C13H13ClN2O
CAS No.	49843-98-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 50 mg/mL (201.0 mM)
	Water: < 1 mg/mL
	Ethanol: 18 mg/mL (72.4 mM)
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 14mg/mL
Synonyms	Selisistat; EX 527; SEN 0014196; EX527; SEN-0014196; SEN0014196; EX-527 Chemical Name: 6-Chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide SMILES Code: O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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