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Description: Lomeguatrib (formerly PaTrin-2) is a novel, potent and selective inhibitor of MGMT (O6-alkylguanine-DNA-alkyltransferase) with anticancer activity. It inhibits MGMT with IC50s of 9 nM and ?6?nM in cell-free assay and MCF-7 cells, respectively.
References: J Med Chem. 1998; 41(26):5265-71; Br J Cancer. 2005; 93(10):1152-6; Int J Cancer. 2000; 85(2):248-52.
PaTrin-2; Lomeguatrib; PaTrin 2; PaTrin2; 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
InChi Key: JUJPKFNFCWJBCX-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1, 3-4H, 2H2, (H3, 12, 13, 14, 15, 16)
SMILES Code: BrC1=CSC(COC2=C3N=CNC3=NC(N)=N2)=C1
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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