hesperadin

Description: Hesperadin is a novel, potent and ATP-competitive inhibitor of human aurora B kinase with potential antitumor activity. It inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. Hersperadin shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy.

References: J Cell Biol. 2003 Apr 28; 161(2):281-94; Mol Microbiol. 2009 Apr; 72(2):442-58.

Hesperadine; Hesperadin;

Hesperadine; (Z)-N-(2-oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide

InChi Key: GLDSKRNGVVYJAB-DQSJHHFOSA-N

InChi Code: InChI=1S/C29H32N4O3S/c1-2-37(35, 36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3, 5-6, 9-16, 19, 30, 32H, 2, 4, 7-8, 17-18, 20H2, 1H3, (H, 31, 34)/b28-27-

SMILES Code: CCS(=O)(NC1=CC2=C(NC(/C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)=O)C=C1)=O