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ag-14361

ag-14361

Item no.	V0305-5mg
Manufacturer	InvivoChem LLC
CASRN	328543-09-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	328543-09-5
Available
Description	InvivoChem Cat #:V0305CAS #:328543-09-5Purity >=98% Description: AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity. It inhibits PARP1 with a Ki of< 5 nM in a cell-free assay. It shows potent antiproliferative activity against various cancer cells and high in vivo antitumor efficacy as well. Description: References: J Natl Cancer Inst. 2004 Jan 7; 96(1):56-67; Clin Cancer Res. 2004 Feb 1; 10(3):881-9; Clin Cancer Res. 2005 Dec 1; 11(23):8449-57. References:
Molecular Weight (MW)	320.39
Formula	C19H20N4O
CAS No.	328543-09-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 12 mg/mL (37.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	4% DMSO+ddH2O: 2mg/mL
Synonyms	AG14361; AG 14361; AG-14361 Chemical Name: 1-(4-((dimethylamino)methyl)phenyl)-8, 9-dihydro-2, 7, 9a-triazabenzo[cd]azulen-6(7H)-one. InChi Key: SEKJSSBJKFLZIT-UHFFFAOYSA-N InChi Code: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H, 10-12H2, 1-2H3, (H, 20, 24) SMILES Code: O=C1C2=C3C(N=C(C4=CC=C(CN(C)C)C=C4)N3CCN1)=CC=C2

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