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pci-34051

pci-34051

Item no.	V0279-5mg
Manufacturer	InvivoChem LLC
CASRN	950762-95-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	950762-95-5
Available
Description	InvivoChem Cat #:V0279CAS #:950762-95-5Purity >=98% Description: PCI-34051 is a novel, potent and specific inhibitor of histone deacetylase 8 (HDAC8) with potential anticancer activity. It inhibits HDAC8 with an IC50 of 10 nM in a cell-free assay, and shows > 200-fold selectivity for HDAC8 over HDAC1 and 6, and 1000-fold higher selectivity over HDAC2/3/10. Description: References: Leukemia. 2008 May; 22(5):1026-34. References:
Molecular Weight (MW)	296.32
Formula	C17H16N2O3
CAS No.	950762-95-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (199.1 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL
Synonyms	PCI-34051; PCI 34051; PCI34051 Chemical Name: N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide InChi Key: AJRGHIGYPXNABY-UHFFFAOYSA-N InChi Code: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10, 21H, 11H2, 1H3, (H, 18, 20) SMILES Code: O=C(C1=CC2=C(C=C1)C=CN2CC3=CC=C(OC)C=C3)NO

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