nu7026

Item no.	V0253-250mg
Manufacturer	InvivoChem LLC
CASRN	154447-35-5
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0253CAS #:154447-35-5Purity >=98% Description: NU7026 is a novel and potent DNA-PK (DNA-dependent protein kinase) with potential antitumor activity. It inhibits DNA-PK with an IC50 of 0.23 uM in cell-free assays, shows 60-fold higher selectivity for DNA-PK over PI3K, and ihas little effects on ATM and ATR. NU 7026 is often combined with PARP-1 inhibitor AG14361 to sensitize tumor cells to radio- or chemo-therapy. When tested with primary PARP-1-/- and cells PARP-1+/+ cells, NU 7026 treatment (< 50 uM) sensitized cells to IR-induced cytotoxicity and reduced clonogenic survival by inhibiting DNA-PK. Description:Description: NU7026 is a novel and potent DNA-PK (DNA-dependent protein kinase) with potential antitumor activity. It inhibits DNA-PK with an IC50 of 0.23 uM in cell-free assays, shows 60-fold higher selectivity for DNA-PK over PI3K, and ihas little effects on ATM and ATR. NU 7026 is often combined with PARP-1 inhibitor AG14361 to sensitize tumor cells to radio- or chemo-therapy. When tested with primary PARP-1-/- and cells PARP-1+/+ cells, NU 7026 treatment (< 50 uM) sensitized cells to IR-induced cytotoxicity and reduced clonogenic survival by inhibiting DNA-PK. References:Blood. 2004 Jun 15; 103(12):4659-65; Br J Cancer. 2005 Oct 31; 93(9):1011-8; Cancer Res. 2009 Mar 1; 69(5):2100-7. References:References: Related CAS: 503465-21-2 (NU-7107); 79105-88-7 (NU-7031); 842122-14-9 (NU-7200); 69541-04-4 (NU-7199)

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Amount: 250mg

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Delivery expected until 9/6/2024