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Description: NU7026 is a novel and potent DNA-PK (DNA-dependent protein kinase) with potential antitumor activity. It inhibits DNA-PK with an IC50 of 0.23 uM in cell-free assays, shows 60-fold higher selectivity for DNA-PK over PI3K, and ihas little effects on ATM and ATR. NU 7026 is often combined with PARP-1 inhibitor AG14361 to sensitize tumor cells to radio- or chemo-therapy. When tested with primary PARP-1-/- and cells PARP-1+/+ cells, NU 7026 treatment (< 50 uM) sensitized cells to IR-induced cytotoxicity and reduced clonogenic survival by inhibiting DNA-PK.
References:Blood. 2004 Jun 15; 103(12):4659-65; Br J Cancer. 2005 Oct 31; 93(9):1011-8; Cancer Res. 2009 Mar 1; 69(5):2100-7.
Related CAS: 503465-21-2 (NU-7107); 79105-88-7 (NU-7031); 842122-14-9 (NU-7200); 69541-04-4 (NU-7199)
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