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Description: GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity. It selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors. It showed potent antiproliferative activity in vitro and high antitumor efficacy in vivo.
References:Cell Rep. 2015 Jun 9; 11(9):1446-57.
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