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Description: AR-A014418 (AR 0133418; SN4521; GSK-3beta inhibitor VIII; AR 014418) is a novel, potent, ATP-competitive, and selective inhibitor of GSK3beta (Glycogen Synthase Kinase 3beta) with the potential for neurodegenerative diseases. It inhibits GSK3beta with an IC50 and Ki of 104 nM and 38 nM in cell-free assays, and exhibits little effects on 26 other kinases tested. AR-A014418 also showed potent antiproliferative activity in vitro by suppressing pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.
References: Cancer Biol Ther. 2014 May; 15(5):510-5; Exp Neurol. 2007 Jun; 205(2):336-46.
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