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afuresertib-gsk2110183

afuresertib-gsk2110183

Item no.	V0169-100mg
Manufacturer	InvivoChem LLC
CASRN	1047644-62-1
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0169CAS #:1047644-62-1Purity >=98% Description: Afuresertib (also named as GSK2110183C) is a potent, orally bioavailable and ATP-competitive Akt inhibitor with potential anticancer activity. It inhibits Akt1, Akt2, and Akt3 with Kis of 0.08 nM, 2 nM, and 2.6 nM, respectively. As an inhibitor of the serine/threonine protein kinase Akt (protein kinase B), Afuresertib has potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Description:Description: References: Cancer Chemother Pharmacol. 2015 Jan; 75(1):183-9; Blood. 2014 Oct 2; 124(14):2162-3. References:References: Related CAS: 1047645-82-8 (Afuresertib HCl / GSK2110183B); 1047634-63-8 (GSK2110183); 2070009-64-0 (Afuresertib-F; GSK-2110183-analog HCl)
Molecular Weight (MW)	427.32
Formula	C18H17Cl2FN4OS
CAS No.	1047644-62-1(Afuresertib / GSK2110183C)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 85 mg/mL (198.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[CH](CC3=CC=CC(F)=C3)CN
Synonyms/Chemical Name	GSK2110183C; GSK-2110183C; GSK 2110183C; GSK2110183 C; GSK2110183-C; GSK2110183C; N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide

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Amount: 100mg

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Delivery expected until 9/6/2024

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