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azd8186

azd8186

Item no.	V0152-250mg
Manufacturer	InvivoChem LLC
CASRN	1627494-13-6
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0152CAS #:1627494-13-6Purity >=98% Description: AZD8186 (also known as AZD) is a novel, potent and selective inhibitor of PI3Kbeta (phosphatidylinositol 3-kinase beta) with potential anticancer activity. It inhibits PI3Kbeta and PI3Kdelta with IC50 of 4 nM and 12 nM, respectively, and showed high selectivity for PI3Kbeta and PI3Kdelta over PI3Kgamma (IC50=675 nM). AZD8186 exhibits significant anti-tumour activity inPTEN-deficient preclinical models, particularly when combined withanti-androgens or the dual mTORC1/2 inhibitor vistusertib (AZD2014). AZD8186 has a potential for treatment of PTEN-deficient tumors. Description: Description: References:J Med Chem. 2015 Jan 22; 58(2):943-62. References:References:

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Amount: 250mg

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Delivery expected until 9/6/2024