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ombitasvir-abt-267

ombitasvir-abt-267

Item no.	V0073-500mg
Manufacturer	InvivoChem LLC
CASRN	1258226-87-7
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0073CAS #:1258226-87-7Purity >=98% Description: Ombitasvir (trade name; Viekira Pak; formerly known as ABT-267) is a novel and potent N-phenylpyrrolidine-based inhibitor of hepatitis C virus (HCV) NS5A with excellent potency, metabolic stability, and pharmacokinetics/PK. Ombitasvir was found to be a pan-genotypic HCV inhibitor with an EC50 range of 1.7-19.3 pM against GT1a, -1b, -2a, -2b, -3a, -4a, and -5a and 366 pM against GT6a. It decreased HCV RNA up to 3.10 log10 IU/mL during 3-day monotherapy in treatment-naive HCV GT1-infected subjects. Ombitasvir has been approved by the Food and Drug Administration (FDA) for use in combination with other antiviral agents (paritaprevir, ritonavir and dasabuvir) under the commercial name of Viekira Pak. References: J Med Chem. 2014 Mar 13; 57(5):2047-57; Antimicrob Agents Chemother. 2015 Feb; 59(2):979-87.
Molecular Weight (MW)	894.11
Formula	C50H67N7O8
CAS No.	1258226-87-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	L-Prolinamide, 2, 2'-(((2S, 5S)-1-(4-(1, 1-dimethylethyl)phenyl)-2, 5-pyrrolidinediyl)di-4, 1-phenylene)bis(N-(methoxycarbonyl)-L-valyl-
Synonyms	Viekira Pak (trade name); ABT-267; ABT267; ABT 267
SMILES Code	InChi Key: ZLLNJSXORCIMOQ-CTWGVMPISA-N InChi Code: InChI=1S/C50H67N7O8/c1-30(2)49(53-46(62)64-8, 44(60)55-28-10-12-40(55)42(51)58)35-18-14-32(15-19-35)38-26-27-39(57(38)37-24-22-34(23-25-37)48(5, 6)7)33-16-20-36(21-17-33)50(31(3)4, 54-47(63)65-9)45(61)56-29-11-13-41(56)43(52)59/h14-25, 30-31, 38-41H, 10-13, 26-29H2, 1-9H3, (H2, 51, 58)(H2, 52, 59)(H, 53, 62)(H, 54, 63)/t38-, 39-, 40-, 41-, 49+, 50+/m0/s1 SMILES Code: CC([CH](NC(OC)=O)C(N1CCC[CH]1C(NC2=CC=C([CH]3CC[CH] CC(C)(C)C(C=C1)=CC=C1N2[CH](C3=CC=C(NC([CH]4N(C([CH](NC(OC)=O)C(C)C)=O)CCC4)=O)C=C3)CC[CH]2C5=CC=C(NC([CH]6CCCN6C([CH](NC(OC)=O)C(C)C)=O)=O)C=C5

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Amount: 500mg

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Delivery expected until 9/6/2024

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