JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website.
Description: Pifithrin-alpha ((PFTalpha) is a novel and potent inhibitor of p53, acting by inhibiting p53 protein transcription and p53-dependent transactivation of p53-responsive genes. It also acts as an aryl hydrocarbon receptor (AhR) agonist. Pifithrin-alpha was firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. Pifithrin-alpha can also induce cell cycle arrest and growth arrest of embryonic stem cells. Treatment of Pifithrin-alpha significantly downregulates the protein lever of Nanog (a pluripotency marker). It is proved that the inhibition of p53 activity caused by Pifithrin-alpha has no effect on ES cell viability.
Reference: Science. 1999 Sep 10; 285(5434):1733-7.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
Request Data Sheet
Request product datasheet
Request safety datasheet
Compare
Add to wishlist
Recommend by mail
Get an offer
Request delivery time
Ask a technical question
Submit a bulk request
sales@hoelzel.de
« Back
Subscribe, get 15% off every fifth order and have your items delivered on time!
Forgot Your Password?
Not yet registered? Create account here!