2-Methoxystypandrone

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

-20°

NF-Κb|||PI3K/Akt/mTOR signaling|||Immunology/Inflammation|||Apoptosis|||Chromatin/Epigenetic|||Proteases/Proteasome|||Cytoskeletal Signaling|||Stem Cells|||Neuroscience|||Angiogenesis|||JAK/STAT signaling