« Back
Home /
VER-246608

VER-246608

Item no.	TMO-T17224-5mg
Manufacturer	TargetMol
CASRN	1684386-71-7
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Smiles	O=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1684386-71-7
Available
Short Description	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
Shipping	cool pack
Storage	-20°
Molecular Weight	552, 96
Pathway	Metabolism\|\|\|PI3K/Akt/mTOR signaling
Target	Dehydrogenase\|\|\|PDK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5mg

available

Delivery expected until 8/16/2024

Express Delivery: Save 3 days

Compare

Add to wishlist

Recommend by mail