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Paraxanthine

Paraxanthine

Item no.	CS-W017214-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	611-59-6
Similar products	611-59-6
Available
CAS	611-59-6
Purity	>98%
MWt	180.17
Formula	C7H8N4O2
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Endogenous Metabolite
Biological Activity	Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. IC50 & Target: Ryanodine Receptor Channels^[1]. In Vitro: When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 uM, increases gradually and remains optimal between 800 and 1000 uM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 uM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 uM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase)^[1].
Research Area	Neurological Disease

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