« Back
Home /
2,5-Dihydroxybenzoic acid

2,5-Dihydroxybenzoic acid

Item no.	CS-W001179-100g
Manufacturer	ChemScene
Amount	100g
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	490-79-9
Available
CAS	490-79-9
Purity	>98%
Formula	C7H6O4
MWt	154.12
Solubility	DMSO : >= 100 mg/mL (648.85 mM)
Clinical Information	No Development Reported
Pathway	Protein Tyrosine Kinase/RTK; Metabolic Enzyme/Protease
Target	FGFR; Endogenous Metabolite
Biological Activity	2, 5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors. IC50 & Target: Fibroblast growth factor^{[2]^{. In Vitro: 2, 5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin^[1]. 2, 5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2, 5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis^[2]. In Vivo: It is verified from in vivo disease models that this group of inhibitors (e.g., 2, 5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases^{[2]^.}}}

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100g

available

Delivery expected until 10/4/2024

Express Delivery: Save 10 days

Compare

Add to wishlist

Recommend by mail