ATB107

455325-51-6

C21H28N8

H2O : < 0.1 mg/mL (insoluble)

Others

ATB107 is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a K_D of 3 uM. IC50 & Target: KD: 3 uM (IGPS)^[1] In Vitro: The minimum inhibitory concentration (MIC) of ATB107 is 0.1 ug/mL for M. tuberculosis H37Ra. ATB107 also has high activity against M. tuberculosis H37Rv, with an MIC of 0.1 ug/mL. All 50 fully susceptible clinical isolates tested are susceptible to ATB107 at 1 ug/mL; of these, 41 (82%) are susceptible to ATB107 at 0.1 ug/mL. The results also show that 67 (83.8%) multidrug-resistant TB (MDR-TB) isolates are susceptible to ATB107 at 1 ug/mL, and 25 (31.3%) isolates are susceptible to ATB107 at 0.1 ug/mL. Results show that the binding ability of ATB107 is well correlated with its concentrations. At the highest concentration of 200 ug/mL, ATB107 can inhibit cell proliferation, with cell survival of about 60%. With the lower concentration of 50 ug/mL, cell survival is more than 80% for ATB107^[1].