RG7713

Item no.	CS-7944-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	920022-47-5
Available
Alternative Names	RO5028442
CAS	920022-47-5
Purity	>98%
Formula	C25H28ClN3O2
MWt	437.96
Solubility	DMSO : 20 mg/mL (45.67 mM; Need ultrasonic)
Clinical Information	Phase 1
Pathway	GPCR/G Protein
Target	Vasopressin Receptor
Biological Activity	RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with K_is of 1 nM (hV1a) and 39 nM (mV1a). IC50 & Target: Ki: 1 nM (hV1a receptor), 39 nM (mV1a receptor)^[1] In Vitro: RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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