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Belizatinib

Belizatinib

Item no.	CS-6943-2mg
Manufacturer	ChemScene
Amount	2mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1357920-84-3
Available
Alternative Names	TSR-011
CAS	1357920-84-3
Purity	>98%
Formula	C33H44FN5O3
MWt	577.73
Solubility	DMSO : >= 300 mg/mL (519.27 mM)
Clinical Information	Phase 2
Pathway	Protein Tyrosine Kinase/RTK; Protein Tyrosine Kinase/RTK; Neuronal Signaling
Target	Trk Receptor; ALK; Trk Receptor
Biological Activity	Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC₅₀ of 0.7?nM for wild-type recombinant ALK kinase. IC50 & Target: IC50: 0.7?nM (ALK)^[1] In Vitro: TSR-011 has antitumour activity in the clinical trials. In Vivo: TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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