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NRC-2694

NRC-2694

Item no.	CS-6754-20mg
Manufacturer	ChemScene
Amount	20mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	936446-61-6
Available
CAS	936446-61-6
Purity	>98%
Formula	C24H26N4O3
MWt	418.49
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Target	EGFR; EGFR
Biological Activity	NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. In Vitro: NRC-2694 at 80 ng (190 nm) concentrations causes comparable inhibition of EGFR expression^[1]. In Vivo: In toxicity studies, the maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (po). NRC-2694 (10 mg/kg) regresses the tumor in mice^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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