C29

363600-92-4

C16H15NO4

DMSO : >= 30 mg/mL (105.16 mM)

Immunology/Inflammation

C29 is a Toll-like receptor 2 (TLR2) inhibitor. IC50 & Target: TLR2^[1] In Vitro: C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1beta gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-kappaB�luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-kappaB�sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-kappaB activation^[1].