Comparison

N-Desmethylclozapine

Item no. CS-6103-25mg
Manufacturer ChemScene
Amount 25mg
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 6104-71-8
Available
Alternative Names
Norclozapine; Desmethylclozapine; Normethylclozapine
CAS
6104-71-8
Purity
>98%
Formula
C17H17ClN4
MWt
312.80
Solubility
DMSO : >= 50 mg/mL (159.85 mM)
Clinical Information
No Development Reported
Pathway
GPCR/G Protein; Neuronal Signaling; Metabolic Enzyme/Protease
Target
Opioid Receptor; Opioid Receptor; Drug Metabolite
Biological Activity
N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of delta-opioid receptor. In Vitro: The IC50s of N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1 uM, 0.38 uM, and 0.67 uM, respectively. The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment, suggesting that the inhibitors act at a stage prior to viral protein translation. N-Desmethylclozapine-treated cells show a >75% reduction in negative-strand RNA levels[1]. N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR, and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaves as an agonist at the delta-opioid receptor in the cerebral cortex and striatum[2]. N-desmethylclozapine (3 uM) greatly decreases the outward current in excitatory neurons, but not in inhibitory neurons. In excitatory neurons, N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine. The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1 uM pirenzepine and 1 uM atropine. N-desmethylclozapine, but not clozapine, suppressed K+ channels via M1 receptors in excitatory cells[3]. N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation. Clozapine, N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production[5]. In Vivo: N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release, respectively. In particular, N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex. However, N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex[4].

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Amount: 25mg
Available: In stock
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