Rbin-1

328023-11-6

C13H12N4S

DMSO : >= 31 mg/mL (120.94 mM); H2O : < 0.1 mg/mL (insoluble)

Others

Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI₅₀ of 136+/-7 nM. IC50 & Target: GI50: 136+/-7 nM (ATPase)^[1] In Vitro: Rbin-1 is a potent and reversible triazinoindole-based inhibitors of eukaryotic ribosome biogenesis. Rbin-1 inhibits recombinant full-length Mdn1’s ATPase activity. Two of the active analogs (Rbin-1 and Rbin-2) inhibit the ATPase activity by 40% at 1 uM. In particular, an analog (Rbin-2) with a bromine substituent at postion-7 is 10-fold more active than Rbin-1 (GI₅₀=14+/-1 nM (Rbin-2); 136+/-7 nM (Rbin-1), n=4, mean+/-SD)^[1].