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D-3263 (hydrochloride)

D-3263 (hydrochloride)

Item no.	CS-5891-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1008763-54-9
Available
CAS	1008763-54-9
Purity	>98%
Formula	C21H32ClN3O3
MWt	409.95
Solubility	DMSO : >= 40 mg/mL (97.57 mM)
Clinical Information	Phase 1
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Target	TRP Channel; TRP Channel
Biological Activity	D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. In Vitro: D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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