ITSA-1

Item no.	CS-5854-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	200626-61-5
Available
CAS	200626-61-5
Purity	>98%
Formula	C13H7Cl2N3O
MWt	292.12
Solubility	DMSO : >= 32 mg/mL (109.54 mM); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	Epigenetics; Cell Cycle/DNA Damage
Target	HDAC; HDAC
Biological Activity	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target:TSA. In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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