IMR-1A

331862-41-0

C13H11NO5S2

DMSO : >= 31 mg/mL (95.28 mM)

Stem Cell/Wnt; Metabolic Enzyme/Protease; Neuronal Signaling

IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitors with an IC₅₀ of 0.5 uM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A^[1]. IC50 & Target: IC50: 0.5 uM (Notch)^[1] In Vivo: IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ca.4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration^[1].