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Litronesib

Litronesib

Item no.	CS-5194-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	910634-41-2
Available
Alternative Names	LY-2523355; KF-89617
CAS	910634-41-2
Purity	>98%
Formula	C23H37N5O4S2
MWt	511.70
Solubility	DMSO : >= 50 mg/mL (97.71 mM)
Clinical Information	Phase 2
Pathway	Cytoskeleton; Cell Cycle/DNA Damage
Target	Kinesin; Kinesin
Biological Activity	Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity. IC50 & Target: Eg5^[1] In Vitro: Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)^[1]. In Vivo: Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors^[1].

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