BG45

Item no.	CS-5084-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	926259-99-6
Available
CAS	926259-99-6
Purity	>98%
Formula	C11H10N4O
MWt	214.22
Solubility	DMSO : >= 48 mg/mL (224.07 mM)
Clinical Information	No Development Reported
Pathway	Epigenetics; Cell Cycle/DNA Damage
Target	HDAC; HDAC
Biological Activity	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 uM, respectively). IC50 value: 289 nM (HDAC3), 2 uM (HDAC1), 2.2 uM (HDAC2), >20 uM (HDAC6) Target: HDAC At concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

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