Suramin (sodium salt)

129-46-4

C51H34N6Na6O23S6

DMSO : 5.6 mg/mL (3.92 mM; Need warming); H2O : >= 200 mg/mL (139.94 mM)

GPCR/G Protein

Suramin sodium salt is a polysulfonated naphthylurea with various biological activities. Suramin sodium salt is a DNA topoisomerase II inhibitor with an IC₅₀ of 5 uM. IC50 & Target: IC50: 5 uM (DNA topoisomerase II)^[3] In Vitro: Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 uM suramin. DNA polymerase alpha is sensitive to lower concentrations of suramin (IC₅₀=8 uM) than is DNA polymerase delta (IC₅₀=36 uM), whereas DNA polymerase beta is relatively insensitive to the drug (IC50 of 90 uM)^[1]. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments^[2]. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC₅₀ of about 5 uM^[3]. In Vivo: Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen^[4].