Dobutamine (hydrochloride)

49745-95-1

337.84

DMSO : >= 33 mg/mL (97.68 mM); H2O : 20 mg/mL (59.20 mM; Need ultrasonic)

GPCR/G Protein; Neuronal Signaling

Dobutamine hydrochloride is a synthetic catecholamine that acts on alpha1-AR, beta1-AR, beta2-AR (alpha-1, beta-1 andbeta-2 adrenoceptors). Dobutamine hydrochloride is a selective beta1-AR agonist, relatively weak activity at alpha1-AR and beta2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
In Vivo: Dobutamine hydrochloride has a rapid onset of action and a short half-life .

Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.

Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.

Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgalphaq*44 mice.

Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.

Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.