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DDR1-IN-1

DDR1-IN-1

Item no.	CS-2808-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1449685-96-4
Available
CAS	1449685-96-4
Purity	>98%
Formula	C30H31F3N4O3
MWt	552.59
Solubility	DMSO : 100 mg/mL (180.97 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	Protein Tyrosine Kinase/RTK
Target	Discoidin Domain Receptor
Biological Activity	DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM)^[1]. IC50 & Target: IC50: 105 nM (DDR1)^[1]. In Vitro: DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC₅₀ = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC₅₀ < 2.5 uM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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