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Dexpramipexole (dihydrochloride)

Dexpramipexole (dihydrochloride)

Item no.	CS-1195-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	104632-27-1
Similar products	104632-27-1
Available
Alternative Names	(R)-Pramipexole (dihydrochloride); R-(+)-Pramipexole (dihydrochloride); KNS-760704 (dihydrochloride)
CAS	104632-27-1
Purity	>98%
MWt	284.25
Formula	C10H19Cl2N3S
Solubility	H2O : 100 mg/mL (351.80 mM; Need ultrasonic); DMSO : >= 100 mg/mL (351.80 mM)
Clinical Information	Launched
Pathway	GPCR/G Protein; Neuronal Signaling
Target	Dopamine Receptor; Dopamine Receptor
Biological Activity	Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist. In Vitro: Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and beta-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.
Research Area	Neurological Disease

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Amount: 100mg

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