ZZW-115 (hydrochloride)

10122-45-9

573.97

H2O : 100 mg/mL (174.23 mM; Need ultrasonic); DMSO : 83.33 mg/mL (145.18 mM; Need ultrasonic)

Apoptosis

ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a K_d of 2.1 uM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and apoptosis. Anticancer activity^[1][2]. In Vitro: ZZW-115 hydrochloride (0.1-33 uM; 72 hours) is efficient in killing cancer cells, with an IC₅₀ in the range of 0.84 uM (ANOR) to 4.93 uM (HN14)^[1].
ZZW-115 hydrochloride (0-100 uM; 24-72 hours) is efficient to kill these tumor cells with an IC₅₀ in the range of 0.42 uM (Hep2G cells) to 7.75 uM (SaOS-2 cells)^[1].
ZZW-115 hydrochloride induces pancreatic cell death by necrosis and apoptosis. ZZW-115 hydrochloride treatment induces a decrease in ATP production and induces a ROS overproduction^[1].
LDH release is significantly higher in ZZW-115 hydrochloride-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115 hydrochloride-treated cells. These experiments demonstrated that ZZW-115 hydrochloride exerted both pronecrotic and proapoptotic effects^[1]. In Vivo: ZZW-115 hydrochloride (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors^[1].
ZZW-115 hydrochloride (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases^[1].