« Back
Home /
PS372424 (hydrochloride)

PS372424 (hydrochloride)

Item no.	CS-0131567-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1596362-29-6
Similar products	1596362-29-6
Available
CAS	1596362-29-6
Purity	>98%
MWt	625.20
Formula	C33H45ClN6O4
Solubility	DMSO : 250 mg/mL (399.87 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein; Immunology/Inflammation
Target	CXCR; CXCR
Biological Activity	PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation^[1]^[2]. In Vitro: PS372424 (100?ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5?min of stimulation^[1]. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3⁺ T cells not in CXCR3^- T cells^[2]. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC₅₀ of 42+/-21 nM^[3].
Research Area	Inflammation/Immunology

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 5mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 10 days

Compare

Add to wishlist

Recommend by mail