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yGsy2p-IN-1

yGsy2p-IN-1

Item no.	CS-0127968-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2415003-97-1
Similar products	2415003-97-1
Available
CAS	2415003-97-1
Purity	>98%
MWt	352.26
Formula	C16H11F3N2O4
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 uM and a K_i of 1.31 uM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)^[1]. IC50 & Target: IC50: 2.75 uM (hGYS1)^[1] Ki: 1.31 uM (wild-type hGYS1)^[1] In Vitro: yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 uM) has IC₅₀s of 7.89 uM and 33.6 uM for yGsy2p-WT and yGsy2p-Y513L^[1]. yGsy2p-IN-1 (100 uM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates^[1].
Research Area	Metabolic Disease

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