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LolCDE-IN-1

LolCDE-IN-1

Item no.	CS-0114381-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1639933-78-0
Similar products	1639933-78-0
Available
CAS	1639933-78-0
Purity	>98%
MWt	345.37
Formula	C21H16FN3O
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : 41.67 mg/mL (120.65 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Anti-infection
Target	Bacterial
Biological Activity	LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity^[1]. IC50 & Target: Bacterial In Vitro: LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane^[1]. LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 deltatolCwith MIC with 8 ug/ml and 0.125 ug/ml^[1]. LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane^[1].
Research Area	Infection

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Amount: 5mg

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Delivery expected until 9/6/2024