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LC3-mHTT-IN-AN1

LC3-mHTT-IN-AN1

Item no.	CS-0106127-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	486443-73-6
Similar products	486443-73-6
Available
CAS	486443-73-6
Purity	>98%
MWt	411.04
Formula	C15H9Br2NO3
Solubility	DMSO : 125 mg/mL (304.11 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	Autophagy
Target	Autophagy
Biological Activity	LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons^[1]. IC50 & Target: mHTT-LC3 Linker Compound In Vitro: LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons^[1].
Research Area	Neurological Disease

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