EACC

Item no.	CS-0103634-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	864941-31-1
Similar products	864941-31-1
Available
CAS	864941-31-1
Purity	>98%
MWt	369.37
Formula	C13H11N3O6S2
Solubility	DMSO : 16.88 mg/mL (45.70 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Autophagy
Target	Autophagy
Biological Activity	EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion^[1]. IC50 & Target: Autophagy^[1] In Vitro: EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function^[1]. EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes^[1]. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17^[1].
Research Area	Infection; Neurological Disease

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