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MI-1061

MI-1061

Item no.	CS-0102051-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1410737-34-6
Similar products	1410737-34-6
Available
CAS	1410737-34-6
Purity	>98%
MWt	582.45
Formula	C30H26Cl2FN3O4
Solubility	DMSO : 300 mg/mL (515.07 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Apoptosis; Metabolic Enzyme/Protease; Apoptosis
Target	Apoptosis; E1/E2/E3 Enzyme; MDM-2/p53
Biological Activity	MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity^[1]. IC50 & Target: IC50: 4.4 nM (MDM2)^[1] Ki: 0.16 nM (MDM2) In Vitro: MI-1061 achieves IC₅₀=100 and 250 nM in the SJSA-1 and HCT-116 p53^+/+ cell lines, respectively, and has IC₅₀>10000 nM in the p53 knockout cell line HCT-116 p53^-/-cell line^[1]. In Vivo: MI-1061 is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice with oral administration^[1].
Research Area	Cancer

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Amount: 10mg

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Delivery expected until 9/6/2024