« Back
Home /
GSK3145095

GSK3145095

Item no.	CS-0094287-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1622849-43-7
Similar products	1622849-43-7
Available
CAS	1622849-43-7
Purity	>98%
MWt	397.38
Formula	C20H17F2N5O2
Solubility	DMSO : 250 mg/mL (629.12 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	Apoptosis
Target	RIP kinase
Biological Activity	GSK3145095 is a RIP1 kinase inhibitor with an IC₅₀ of 6.3 nM ^[1]. IC50 & Target: IC50: 6.3 nM (RIP1 kinase )^[1] In Vitro: GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC₅₀ = 1.6 nM), cell death as measured by LDH release (IC₅₀ = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1beta production, either as absolute levels for protein, or fold changes in mRNA expression (IC₅₀ = 0.4 nM) ^[1].
Research Area	Cancer

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 1 days

Compare

Add to wishlist

Recommend by mail