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NVP-BHG712

NVP-BHG712

Item no.	CS-0094280-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	940310-85-0
Available
Alternative Names	BHG712
CAS	940310-85-0
Purity	>98%
Formula	C26H20F3N7O
MWt	503.48
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Protein Tyrosine Kinase/RTK
Target	Ephrin Receptor
Biological Activity	NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC₅₀ values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively^[1]^[2]. IC50 & Target: IC50: 3.3 nM (EphA2), 3 nM (EphB4)^[2]. In Vitro: NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation^[2]. In Vivo: NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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