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SPOP-IN-6b

SPOP-IN-6b

Item no.	CS-0087523-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2136270-20-5
Similar products	2136270-20-5
Available
CAS	2136270-20-5
Purity	>98%
MWt	500.59
Formula	C28H32N6O3
Solubility	DMSO : 10 mg/mL (19.98 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88^[1]. IC50 & Target: SPOP^[1] In Vitro: SPOP-IN-6b a SPOP inhibitor with an IC₅₀ of 3.58 uM in cell assay^[1]. SPOP-IN-6b (0.1-3.0 uM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content^[1]. SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination^[1]. In Vivo: SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP^[1].
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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