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MLT-748

MLT-748

Item no.	CS-0087009-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1832578-30-9
Similar products	1832578-30-9
Available
CAS	1832578-30-9
Purity	>98%
MWt	492.32
Formula	C19H19Cl2N9O3
Solubility	DMSO : >= 250 mg/mL (507.80 mM)
Clinical Information	No Development Reported
Pathway	NF-kappaB; Metabolic Enzyme/Protease
Target	MALT1; MALT1
Biological Activity	MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC₅₀ of 5 nM^[1]. IC50 & Target: IC50: 5 nM (MALT1)^[1] Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))^[1] In Vitro: MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (K_d, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (K_d, 42 nM)^[1]. MLT-748 (0-2 uM) stabilizes cellular MALT1-W580S, with an EC₅₀ of 69 nM^[1]. MLT-748 (2 uM, 24 hours) increases the phosphorylation of p65 and IkappaBalpha in MALT1^mut/mut patient immortalized B cells^[1].
Research Area	Inflammation/Immunology

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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