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UBCS039

UBCS039

Item no.	CS-0086992-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	358721-70-7
Available
CAS	358721-70-7
Purity	>98%
Formula	C16H13N3
MWt	247.29
Solubility	DMSO : 125 mg/mL (505.48 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Autophagy; Epigenetics; Cell Cycle/DNA Damage
Target	Autophagy; Sirtuin; Sirtuin
Biological Activity	UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC₅₀ of 38 uM^[1]. IC50 & Target: EC50: 38 uM (SIRT6)^[1]. In Vitro: UBCS039 (75 uM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells^[2]. UBCS039 leads to autophagosome accumulation in human cancer cells^[2]. UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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