QM385

Item no.	CS-0084924-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2093421-02-2
Similar products	2093421-02-2
Available
CAS	2093421-02-2
Purity	>98%
MWt	409.37
Formula	C17H18F3N7O2
Solubility	DMSO : 125 mg/mL (305.35 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC₅₀ of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability^[1]. IC50 & Target: IC50: 1.49 nM (Sepiapterin reductase)^[1] In Vitro: QM385 effectively inhibits the proliferation of human CD4⁺ T cells at low doses^[1].
Research Area	Inflammation/Immunology

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