Ly93

Item no.	CS-0082022-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1883528-69-5
Similar products	1883528-69-5
Available
CAS	1883528-69-5
Purity	>98%
MWt	332.40
Formula	C21H20N2O2
Solubility	DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC₅₀ of 91 nM^[1]. In Vivo: Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice^[1]. Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice^[1].
Research Area	Inflammation/Immunology

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