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LY3295668

LY3295668

Item no.	CS-0080775-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1919888-06-4
Available
Alternative Names	AK-01
CAS	1919888-06-4
Purity	>98%
Formula	C24H26ClF2N5O2
MWt	489.95
Solubility	DMSO : 150 mg/mL (306.15 mM; Need ultrasonic)
Clinical Information	Phase 2
Pathway	Cell Cycle/DNA Damage; Epigenetics
Target	Aurora Kinase; Aurora Kinase
Biological Activity	LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with K_i values of 0.8 nM and 1038 nM for AurA and AurB, respectively. IC50 & Target: Ki: 0.8 nM (AurA)^[1]. In Vitro: LY3295668 is a highly specific Aurora-A kinase inhibitor, with K_i values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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